| mir-19 microRNA precursor family | |
|---|---|
| Predicted secondary structure and sequence conservation of mir-19 | |
| Identifiers | |
| Symbol | mir-19 |
| Rfam | RF00245 |
| miRBase | MI0000073 |
| miRBase family | MIPF0000011 |
| Other data | |
| RNA type | Gene; miRNA |
| Domain(s) | Eukaryota |
| GO | 0035195 0035068 |
| SO | 0001244 |
The miR-19 microRNA precursor is a small non-coding RNA molecule that regulates gene expression. Within the human and mouse genome there are three copies of this microRNA that are processed from multiple predicted precursor hairpins:[1][2] [3]
miR-19 has now been predicted or experimentally confirmed in a wide range of vertebrate species (MIPF0000011). In this case the mature sequence is excised from the 3' arm of the hairpin precursor.
It has been shown that the 3' UTR of the ATXN1 gene contains 3 target sites for miR-19, and that this microRNA shows moderate down regulation of reporter genes containing the ATXN1 3' UTR. ATXN1 is also regulated by miR-101, and miR-130.[4]
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